Synthesis and cytotoxic activity of some novel 2’-hydroxychalcones containing murrayafoline A

2’-Hydroxychalcones and murrayafoline A, a natural compounds isolated from Glycomis stenocarpa, have been reported to the promising anti-cancer activity. In this study, series of 2'-hydroxychalcones containing A (MuA) 6a-f were achieved by Claisen-Schmidt condensation key intermediate 5'-(1-methoxy-3-methyl-carbazolyl)methyl-2'-hydroxyacetophenone 4 with various aldehydes 5a-f purpose combining activity two precusors. Their structures determined NMR MS spectral data. Screening for cytotoxicity showed that 6a-6d expressed cytotoxic activity, notably compound 6a displayed against all tested cell lines LU-1, Hep-G2, MCF-7, P338, SW480 IC50 values ranging 23.97 80.19 μg/mL. Clearly, substitution at position N-H group led decline in obtained derivatives. This finding suggests presence might be play crucial role